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  Today's Knowledge Share: Healing Halogens  A significant number of drugs are halogenated. Typically, insertion of halogen atoms on hit or lead compounds is performed to occupy the binding site of molecular targets in order to improve the drug−target binding affinity and/or reduce metabolism. 14 out of the 50 molecules approved by the FDA in 2021 contain halogens. The introduction of F onto a chemical scaffold is able to infer changes that affect the physicochemical properties and the conformation of a molecule. Being the most electronegative element in the periodic table, F plays an important role in the modulation of pKa of neighboring functionalities. Substituting F for H on aromatic groups is also well known to improve metabolic stability. Lipophilicity is also affected by the addition of F onto aliphatic and aromatic scaffolds. The monofluorination or trifluoromethylation of saturated alkyl groups usually decreases the lipophilicity due to the strong electron-withdrawing capa

Geological Survey of India has for the first time established Lithium inferred resources (G3) of 5.9 million tonnes in Salal-Haimana area of Reasi District of Jammu & Kashmir (UT). This report along with 15 other resource bearing geological reports (G2 & G3 stage) and 35 Geological memorandums were handed over to respective state governments during the 62nd Central Geological Programming Board (CGPB) meeting held on 09th February 2023. Out of these 51 mineral blocks, 5 blocks pertains to gold and other blocks pertains to commodities lke potash, molybdenum, base metals etc. spread across 11 states of Jammu & Kashmir (UT), Andhra Pradesh, Chhattisgarh, Gujarat, Jharkhand, Karnataka, Madhya Pradesh, Odisha, Rajasthan, Tamil Nadu and Telangana.. The blocks were prepared based on the work carried out by GSI from field seasons 2018-19 to till date. Source:https://pib.gov.in/PressReleasePage.aspx?PRID=1897799

  Today's Knowledge Share: Do you know about Cannabis Trichomes and Resin Glands? Cannabis trichomes appear as sticky translucent whitish to amber resin on ripening cannabis flowers, leaves, and branches. Trichomes may be made of hairs, glandular hairs, scales, and papillae. They grow on the appendages of plants, such as cannabis, as well as algae and lichens. The production of trichomes can be observed in many species of plants throughout nature, taking on various physical forms as well as serving many different purposes. For example, trichomes found on some carnivorous plants aid in helping to catch prey. In cannabis, trichomes function as a defense mechanism. When female cannabis plants begin to produce flowers in the wild, they often become vulnerable to various insects and animals as well as non-living environmental variables such as potentially harmful UV rays. Trichomes serve as a deterrent for animals because their bitter taste and strong aromas render cannabis flowers unpa

  TYPE 4 COMPOSITE CNG/H2 CYLINDER Project report is available on a competitive pricing-Moving Toward a user friendly and a safer environment. This report has covered the following topics: ■An overview landscape of the market ■Global Natural Gas Vehicles (NGVs) market ■ Latest technological advancements in Type 3/4 COMPOSITE CNG Cylinder market ■ Merger & Acquisition  ■ Major players share ■ Investment structure ■ Standards ■ costing and certification ■ Automotive Type 4 CNG/H2 Composite cylinder market in India and the rest of the world ■ Bulk transportation Type 4 CNG Composite cylinder market in India and the rest of the world ■ Swot analysis ■ The durability of the Type 4 Composite CNG cylinder ■ Initial Project cost to set up CNG/H2 manufacturing line ■ Strategic Model followed by the KEY PLAYERS ■ Economic efficiency & safety,  ■ The Future Trends in Composite CNG/HYDROGEN Cylinder market Interested companies/Professionals do write to me at  rosaram211@gmail.com  to get m

  Today's Knowledge Share: I completed a failure analysis on a safety clip, which had failed an impact test at -30 °C. The parts are specified to be able to withstand the cold temperature impact test, and the failures were of serious concern due to potential safety issues. The parts were injection molded from an unfilled, impact modified nylon 6/6 resin. The fractographic examination indicated that the cracking was initiated through a brittle fracture mechanism, characterized by a relatively high crack propagation rate, and a significant amount of driving energy. In particular, this was characterized by the presence of stepwise-cracking associated with crack bifurcation, as well as secondary cracking. Additionally, the fracture surface within the origin zone showed a very smooth morphology, without micro ductility. The observed features were indicative of a high level of energy within the fracture as it propagated from the origin. The fracture surface characteristics were consisten