ORNL Researchers Modify Microbes to Simplify Renewable Chemicals’ Production
Oak Ridge National Laboratory scientists have modified a single microbe to simultaneously digest five of the most abundant components of lignocellulosic biomass, a big step forward in the development of a cost-effective biochemical conversion process to turn plants into renewable chemicals . Engineering Bacteria to Produce Renewable Chemicals The team engineered the Pseudomonas putida bacterium to consume glucose, xylose, arabinose, coumaric acid and acetic acid in a single bioreactor, eliminating the need for multiple tanks and microbes for each of those components. The one-pot process also breaks down lignin — traditionally a waste product of biomass conversion — so that every part of the plant can be used to create valuable products. “ We were pleasantly surprised at how quickly and well the microbe consumed these components, as they are structurally different and utilized via very different pathways. You had all of this carbon converging in the central metabolism and b...